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Overexpression of cytoplasmic glycine and D-serine dehydratase (GSD) in human prostate cancer cells increases the growth rate of androgen-independent PC-3 cells.
Glycine and D-serine have been shown to be important trophic factors for normal and cancer cells. It was our hypothesis that human prostate cancer cells would be dependent on glycine as a trophic factor. Prostate cancer cells were cultured in media containing glycine or D-serine as the sole carbon source. Cell proliferation was measured by MTT assay. D-serine dehydratase (GSD) was determined by immunocytochemistry. In the human prostate cancer cell lines PC-3 and DU145, a marked response to glycine as compared with D-serine was observed. Glycine deprivation resulted in increased apoptosis in prostate cancer cells. PC-3 cells cultured in D-serine medium (unlike the control cells) exhibited increased proliferation. This was associated with increased expression of GSD. Tumors from patient biopsies demonstrated increased expression of GSD when compared with non-tumor adjacent prostate. We conclude that prostate cancer cells are dependent on glycine for cell proliferation, and D-serine dehydratase expression is increased in advanced prostate cancer, which may explain the increased growth rate of prostate cancer. Glycine may be an important trophic factor in prostate cancer.Our experience with intraocular lens in children.
In the last 15 years, 70 patients with cataract and 13 with senile opacity of the cornea were operated on by the authors for cataract. In our series, cataract extraction with intraocular lens implantation was performed in 70 children aged 6-17 years. The indication for surgery was myopia, hyperopia and astigmatism of up to 6 diopters. A self-designed and manufactured intraocular lens with a polished optic and a silicone haptic was implanted in 29 eyes. In the 35 remaining eyes (including 7 in children under 12 years old) a sharp, diffractive, intraocular lens was implanted. The following parameters were followed up in each patient: refraction, best corrected visual acuity, presence of complications and the assessment of parents’ and children’s quality of life.Q:
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Easy Translator Free
A useful, albeit simple, tool for simple translations
Platform: Windows
Status: Beta
Website:
A:
GetText has a free trial version. It supports a selection of languages and is much better than Google Translate.
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There’s an app on the play store called Translate with Voice. It’s free and it supports over 300 languages.
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Google Translate. I know that sounds silly but it is and, from what I’ve read, it is the best solution.
It does what it is supposed to do, and it’s free and easy to use.
S. Courtney Blatchford
South Carolina Times-News
GREENVILLE, S.C. — A woman charged with battery after allegedly choking a woman at a South Carolina Waffle House has been released on bond, her attorney said Wednesday.
The incident happened Monday night at the Waffle House located at the corner of Pendleton Road and Lee Highway in Greenville, according to a police report.
The woman was being interviewed at the Greenville Police Department when she became agitated and started talking about food, the report said. The report said she then began choking the woman.
The Greenville Times-News reported earlier this month that the suspect, Deborah Shannon, 23, of South Carolina, had been involved in a fight with an unidentified woman in 2016. That woman was charged with battery for allegedly throwing food at Shannon during the fight.
On Monday, Shannon allegedly became upset with the Greenville woman because she told Shannon she was going to take out an order for Shannon’s friend who was waiting in the drive-thru line and then got in her car and left, according to the report.
The report said Shannon followed her and when she pulled into her driveway, Shannon “got out of her vehicle and threw the female to the ground.”
The report did not say whether the victim was the same woman involved in the 2016 incident.
Her attorney said in a statement that the charges against his client have no merit. He said they will file a motion to dismiss the charges.
“She was picked up in a very crowded Waffle House, immediately after finishing dinner, and thrown to the ground,” the statement said. “Deborah clearly has the right to defend herself. It appears that the victim is a witness in an unrelated incident. Since Deborah was in a
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DOWNLOADEasy Translator APP
Easy Translator – Translate Text on the Web by Easy Translator – OnlineTranslation – Simple, free online translator.
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Tutorial – Easy Translator Application
Tutorial – Easy Translator Application
Tutorial – Easy Translator Application
Easy Translator – Translate Text on the Web by Easy Translator – OnlineTranslation – Simple, free online translator.
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System Requirements For Easy Translator:
If you see the following error please upgrade your device to the most recent firmware and try again.
“This application requires Android 4.2.2 or higher. Please upgrade to the latest version of Android”
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