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Where can I download a copy of the brochure for ProBus for free?. additional brochures for ProBus. There are two versions of the ProBus Simulator free download.These are available for free via.F-induced activation of Hh/Gli pathway is of particular interest because Hh signaling is often upregulated in cancer cells, including glioma cells, and can contribute to the induction of cancer stem cells \[[@B57]-[@B59]\]. Consistent with these observations, we found that the increase of SMO protein level in response to FGF was time-dependent (Figure [6A](#F6){ref-type=”fig”}) and the activation of Hh/Gli pathway was demonstrated by an enhanced expression of Hh target genes such as *Gli1, Gli2, Gli3, Ptch1, and*others (Figure [6B](#F6){ref-type=”fig”} and data not shown). These results suggest that in addition to promoting cell migration, FGF might also drive cancer stem cell tumorigenesis via the activation of Hh/Gli signaling.

FGF/RAS crosstalk has been previously described. RAS can be activated by FGF in stromal cells and many models showed that FGF/RAS interaction could promote the tumor growth and angiogenesis of a wide spectrum of cancer cells \[[@B60]\]. In our study, we observed that RAS activation and FGF responsiveness were not absolutely correlative in CD133+ cells. In the presence of an inhibitor of RAS, there was no increase of FGF-induced PDGFRβ expression (Figure [4A](#F4){ref-type=”fig”}) and cell migration (Figure [4B](#F4){ref-type=”fig”}) in CD133+ cells. Also, RAS
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