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It is well established that iron metabolism plays an essential role in the biosynthesis of the steroid hormones and in the pathophysiology of the male sexual dysfunctions. The objective of the present work was to review the current evidence on the effect of iron deficiency on the production of testosterone. At least five components must be considered when assessing the relationship between iron and testosterone production in vivo: 1) the mechanisms of iron supply to developing Sertoli cells; 2) the relationship between intracellular iron and testicular activity; 3) the relationship between iron and transcriptional control of the aromatase gene, the key enzyme in estrogen biosynthesis, and 4) finally, the relationship between iron and testosterone output. We also address in vitro studies using testicular slices. The relationship between iron supply and testosterone synthesis is complex. A combination of mechanisms may be involved: 1) transcriptional regulation of the aromatase gene by iron; 2) iron-dependent non-transcriptional regulation of the aromatase gene; 3) regulation of aromatase gene expression by free radical degradation of the major iron-binding protein transferrin; 4) regulation of cellular cholesterol availability by transferrin; 5) direct impairment of cholesterol availability for steroid synthesis. Recent work by our laboratory using a rat model of dietary iron depletion suggests that the major mechanism is transcriptional control of aromatase by iron. This model may be directly relevant to human infertility.MicroRNA (miR) regulation of the immune response.
MicroRNAs (miRNAs) are short, non-coding, single-stranded RNAs that regulate the
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Barring a surprise of sorts, the Miami Marlins are going to break their losing streak and make good on a decision to tinker with their roster come the start of the 2013 season.
The move they’re considering is to trade catcher Mike Zunino to the Seattle Mariners.
Bob Nightengale of USA TODAY Sports and CBS Sports, citing multiple sources, reported on Wednesday that the Marlins are in the process of trading Zunino to Seattle, who acquired the 23-year-old backstop from Seattle in last summer’s deal that sent lefty Erik Bedard to the Mariners.
Because the Marlins can’t afford to pay Zunino the major league minimum of $507,000, that would force them to either find another team to take the $675,000 or $825,000 (maximum) that Zunino is owed next season or pay the fine that comes with playing him for less than the league minimum.
According to Nightengale, that “will take several days, possibly weeks” to sort out.
MORE MLB COVERAGE:
MLB Tracker: Latest moves making news in MLB | Latest buzz | Hot stove
MLB Standings: Holds, crumbles and who else is hot
Zunino’s new Marlins team: Just how good can he be?
As to the trade itself, it certainly figures that the Mariners would be willing to pay up for Zunino.
Tom Frank of MLB.com reported back in August that the Marlins were willing to trade Z
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