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. me a glass of water or some food, and rather than give me a simple ‘yes’ or ‘no’, you gave me a detailed and thoughtful response. You took time to think carefully, and I loved it. Of course, you didn’t need to explain yourself, but your willingness to did make me love you all the more. I didn’t know a brother like you existed, and I hope we’ll be friends for a very long time.” She paused for a moment, slowly looking over at her brother, “I love you.”
“Uhh… I love you too, Claire.”
As the two of them shared a loving embrace, Yang sighed in pure bliss. For her, it was worth it to wait for the happy ending. And since she was the perfect person to give the bad news to, she had no regrets.
As the two of them continued to hug, Weiss, who was sitting silently by herself, lost patience with the newbie of the group. “Well, you think this is a touching moment, but I’m leaving.” She got up and grabbed her sword, “I’m heading home to see how the rest of the world is doing. If you try anything, I’ll be back.”
The other two were absolutely shocked at Weiss’s reaction. It was Yang who spoke up first, “You can’t leave! Weiss, we haven’t even started our missions yet!”
“I’m not leaving, Yang, I’m going home.” She gave her sister a deadly look, then she turned to Blake and Raven, “Now, I want you two to get these two out of here. If they try to escape, you know what to do.”
The two of them didn’t say a word, knowing exactly what their leader wanted, and they got up and escorted the three teenagers out of
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Our observation that B cells express the alpha 4 beta 1 integrin (VLA-4) was followed by the demonstration that haematopoietic progenitor cells (HPCs) also express this integrin and that it was located on the cell surface. This allowed us to investigate the mechanism of engraftment of HPCs in normal and reconstituted bone marrow chimeras. The temporal sequence of appearance of VLA-4 and of mature B cells in the thymus of normal mice, of reconstituted mice reconstituted with syngeneic HPCs, and of mice reconstituted with HPCs of other strains, was determined by immunohistological staining and detection of an anti-VLA-4 monoclonal antibody (mAb). No evidence of VLA-4 expression was observed on haematopoietic cells of normal mice thymus. In all experiments, one or two subsets of thymocytes, containing the rare cells positive for VLA-4, were observed. The cells positive for VLA-4 were found in the medulla but not in the cortex, and they were not the immunoglobulin-positive (Ig+) thymocytes. These cells were also not present in normal mice thymi of other strains or in mice reconstituted with bone marrow of other strains. In reconstituted mice reconstituted with syngeneic HPCs, the appearance of VLA-4 and of mature B cells was coincident. The appearance of cells positive for VLA-4 was delayed by one day in mice reconstituted with HPCs of other strains, for instance, in mice reconstituted with HPCs from CBA-jagged or C57BL/6-green fluorescent protein (GFP) mice. On the basis of these observations, we conclude that VLA-4 expression is a differentiation marker on B cells but not on
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